The museum's collection includes Wytheville's first fire truck, c-1855, early farming equipment and tools, military uniforms, Civil War displays, photographs of early schools and churches and artifacts from the mining industry. The selected topics include the early settlement of Wythe County, the development of Wytheville, the Civil War, World War 1, Edith Bolling Wilson, Wytheville as a tourism destination, and Wytheville as a polio town. Most items came from the Museum's collections, but some images came from the Woodrow Wilson Birthplace, the Library of Virginia, the Museum of the Confederacy and Virginia Tech's special collection. Fort Chiswell excavation pieces came from the Virginia Department of Historic Resources.